Characters

Dr. Gregory House is the protagonist of this drama. An infectious disease and nephrology specialist, he thrives on the challenge of solving medical puzzles in order to save lives. House is also often portrayed as lacking empathy and sympathy for his patients. Dr. James Wilson once says that while "some doctors have the messiah complex — they need to save the world", House has "a Rubik's complex" — he needs "to solve the puzzle."

Dr. Lisa Cuddy is the Dean of Medicine at the Princeton Plainsboro Teaching Hospital (fictional). Her relationship to Dr. House is employer to employee. she specializes in Endocrinology. Although she is the employer of Dr. House, their relationship with each other is very interesting. They have some sexual tension between them.
Dr. Robert Chase is one of the three diagnostics medicine fellow of Dr. House. He has a interesting personality. He loves the job and he is willing to do anything to keep it. When Edward Vogler (season 2) puts pressure on House. he is willing to pass information to Vogler. As the show progresses, he developes some real respect and loyalty to House. Chase has, at times, shown a shrewd capability of deducing people's motives, rather similar to House.
Dr. Eric Foreman is also in House's diagnostics team. He is a Neurologist. Little is known about Foreman's past, although it has been suggested that his family was not very well-off and his parents are currently living on a pension. Foreman was also a former juvenile delinquent who once burgled houses and stole cars; House claims that this was a major factor in his decision to hire Foreman.

Dr. Allison Cameron is another doctor in the fellowship of Dr. House. She specializes in Immunology. Cameron is known for her honesty, sincerity, idealism and strong ethical center. She is hyperopic and an atheist. Cameron objects to House's reliance on deceiving their patients and has gone head-to-head with him several times on the issue.

Dr. James Wilson specializes in Oncology. He is the only friend of Dr. House. Wilson has a history of three failed marriages. The third season introduces his second wife, Bonnie, who is a realtor. His third marriage with Julie takes place during the first and the second season. House once refers to Wilson as "a buddy of mine people say 'Thank you' to when he tells them they are dying." Wilson uses his skill to help House by convincing a patient to authorize treatment.